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Title 15 - Commerce and Foreign Trade last revised: Sep 26, 2025
All TitlesTitle 15Chapter VIIPart 745Appendix - Supplement No. 1 to Part 745—Schedules of Chemicals
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Appendix - Supplement No. 1 to Part 745—Schedules of Chemicals
CAS
registry No.
Schedule 1
A. Toxic Chemicals:
1. Family: O-Alkyl(≤C10, incl. cycloalkyl) alkyl (Me, Et, n-Pr or i-Pr)- phosphonofluoridates
Not limited to the following examples:
Sarin: O-Isopropyl methylphosphonofluoridate107-44-8
Soman: O-Pinacolyl methylphosphonofluoridate96-64-0
2. Family: O-Alkyl (≤C10, incl. cycloalkyl) N,N-dialkyl (Me, Et, n-Pr or i-Pr) phosphoramidocyanidates
Not limited to the following example:
Tabun: O-Ethyl N,N-dimethyl phosphoramidocyanidate77-81-6
3. Family: O-Alkyl (H or ≤C10, incl. cycloalkyl) S-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonothiolates and corresponding alkylated or protonated salts
Not limited to the following example:
VX: O-Ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate50782-69-9
4. Sulfur mustards:
2-Chloroethylchloromethylsulfide2625-76-5
Mustard gas: Bis(2-chloroethyl)sulfide505-60-2
Bis(2-chloroethylthio)methane63869-13-6
Sesquimustard: 1,2-Bis(2-chloroethylthio)ethane3563-36-8
1,3-Bis(2-chloroethylthio)-n-propane63905-10-2
1,4-Bis(2-chloroethylthio)-n-butane142868-93-7
1,5-Bis(2-chloroethylthio)-n-pentane142868-94-8
Bis(2-chloroethylthiomethyl)ether63918-90-1
O-Mustard: Bis(2-chloroethylthioethyl)ether63918-89-8
5. Lewisites:
Lewisite 1: 2-Chlorovinyldichloroarsine541-25-3
Lewisite 2: Bis(2-chlorovinyl)chloroarsine40334-69-8
Lewisite 3: Tris(2-chlorovinyl)arsine40334-70-1
6. Nitrogen mustards:
HN1: Bis(2-chloroethyl)ethylamine538-07-8
HN2: Bis(2-chloroethyl)methylamine51-75-2
HN3: Tris(2-chloroethyl)amine555-77-1
7. Saxitoxin35523-89-8
8. Ricin9009-86-3
13. Family: P-alkyl (H or ≤C10, incl. cycloalkyl) N-(1-(dialkyl(≤C10, incl. cycloalkyl)amino))alkylidene(H or ≤C10, incl. cycloalkyl) phosphonamidic fluorides and corresponding alkylated or protonated salts
Not limited to the following examples:
N-(1-(di-n-decylamino)-n-decylidene)-P-decylphosphonamidic fluoride2387495-99-8
Methyl-(1-(diethylamino)ethylidene)phosphonamidofluoridate2387496-12-8
14. Family: O-alkyl (H or ≤C10, incl. cycloalkyl) N-(1-(dialkyl(≤C10, incl. cycloalkyl)amino))alkylidene(H or ≤C10, incl. cycloalkyl) phosphoramidofluoridates and corresponding alkylated or protonated salts
Not limited to the following examples:
O-n-Decyl N-(1-(di-n-decylamino)-n decylidene)phosphoramidofluoridate2387496-00-4
Methyl (1-(diethylamino)ethylidene)phosphoramidofluoridate2387496-04-8
Ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate2387496-06-0
15. Methyl-(bis(diethylamino)methylene)phosphonamidofluoridate2387496-14-0
16. Carbamates (quaternaries and bisquaternaries of dimethylcarbamoyloxypyridines)
16.1. Family: Quaternaries of dimethylcarbamoyloxypyridines: 1-[N,N-dialkyl(≤C10)-N-(n-(hydroxyl, cyano, acetoxy)alkyl(≤C10)) ammonio]-n-[N-(3-dimethylcarbamoxy-α-picolinyl)-N,N-dialkyl(≤C10) ammonio]decane dibromide (n=1-8)
Not limited to the following example:
1-[N,N-dimethyl-N-(2-hydroxy)ethylammonio]-10-[N-(3-dimethylcarbamoxy-α-picolinyl)-N,N-dimethylammonio]decane dibromide77104-62-2
16.2. Family: Bisquaternaries of dimethylcarbamoyloxypyridines:1,n-Bis[N-(3-dimethylcarbamoxy-α-picolyl)-N,N-dialkyl(≤C10) ammonio]-alkane-(2,(n-1)-dione) dibromide (n=2-12)
Not limited to the following example:
1,10-Bis[N-(3-dimethylcarbamoxy-α-picolyl)-N-ethyl-N- methylammonio]decane-2,9-dione dibromide77104-00-8
B. Precursors:
9. Family: Alkyl (Me, Et, n-Pr or i-Pr) phosphonyldifluorides
Not limited to the following example:
DF: Methylphosphonyldifluoride676-99-3
10. Family: O-Alkyl (H or ≤C10, incl. cycloalkyl) O-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonites and corresponding alkylated or protonated salts
Not limited to the following example:
QL: O-Ethyl O-2-diisopropylaminoethyl methylphosphonite57856-11-8
11. Chlorosarin: O-Isopropyl methylphosphonochloridate1445-76-7
12. Chlorosoman: O-Pinacolyl methylphosphonochloridate7040-57-5
Schedule 2
A. Toxic Chemicals:
1. Amiton: O,O-Diethyl S-[2-(diethylamino)ethyl] phosphorothiolate and corresponding alkylated or protonated salts78-53-5
2. PFIB: 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl)-1-propene382-21-8
3. BZ: 3-Quinuclidinyl benzilate6581-06-2
B. Precursors:
4. Family: Chemicals, except for those listed in Schedule 1, containing a phosphorus atom to which is bonded one methyl, ethyl or propyl (normal or iso) group but not further carbon atoms,
Not limited to the following examples:
Methylphosphonyl dichloride676-97-1
Dimethyl methylphosphonate756-79-6
Exemption: Fonofos: O-Ethyl S-phenyl ethylphosphonothiolothionate944-22-9
5. Family: N,N-Dialkyl (Me, Et, n-Pr or i-Pr) phosphoramidic dihalides
6. Family: Dialkyl (Me, Et, n-Pr or i-Pr) N,N-dialkyl (Me, Et, n-Pr or i-Pr)-phosphoramidates
7. Arsenic trichloride7784-34-1
8. 2,2-Diphenyl-2-hydroxyacetic acid76-93-7
9. Quinuclidine-3-ol1619-34-7
10. Family: N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethyl-2-chlorides and corresponding protonated salts
11. Family: N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethane-2-ols and corresponding protonated salts
Exemptions: N,N-Dimethylaminoethanol and corresponding protonated salts108-01-0
N,N-Diethylaminoethanol and corresponding protonated salts100-37-8
12. Family: N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethane-2-thiols and corresponding protonated salts
13. Thiodiglycol: Bis(2-hydroxyethyl)sulfide111-48-8
14. Pinacolyl alcohol: 3,3-Dimethylbutane-2-ol464-07-3
Schedule 3
A. Toxic Chemicals:
1. Phosgene: Carbonyl dichloride75-44-5
2. Cyanogen chloride506-77-4
3. Hydrogen cyanide74-90-8
4. Chloropicrin: Trichloronitromethane76-06-2
B. Precursors:
5. Phosphorus oxychloride10025-87-3
6. Phosphorus trichloride7719-12-2
7. Phosphorus pentachloride10026-13-8
8. Trimethyl phosphite121-45-9
9. Triethyl phosphite122-52-1
10. Dimethyl phosphite868-85-9
11. Diethyl phosphite762-04-9
12. Sulfur monochloride10025-67-9
13. Sulfur dichloride10545-99-0
14. Thionyl chloride7719-09-7
15. Ethyldiethanolamine139-87-7
16. Methyldiethanolamine105-59-9
17. Triethanolamine102-71-6
Note to Supplement 1:

The numerical sequence of the “Schedule 1” Toxic Chemicals and Precursors is not consecutive so as to align with the December 23, 2019, consolidated textual changes to “Schedule 1” of the Annex on Chemicals to the Chemical Weapons Convention (CWC), which reflect the decisions adopted by the CWC Conference of the States Parties in November 2019.

 [86 FR 942, Jan. 7, 2021]
authority: 50 U.S.C. 1701
source: 64 FR 27143, May 18, 1999, unless otherwise noted.
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